Screening to Prevent Osteoporotic Fractures

Alendronate treatment to prevent osteoporotic fractures.

Alendronate sodium, an aminobisphosphonate, has been approved by the Food and Drug Administration for the prevention and treatment of osteoporosis in postmenopausal women, thus providing an effective alternative to estrogen replacement therapy in women who cannot or will not take estrogen. Large, randomized, controlled trials have demonstrated approximately a 50% reduction in vertebral, hip, an...

are physicians ready to prevent osteoporotic fractures in hemodialysis patients?

Are Physicians Ready to Prevent Osteoporotic Fractures in Hemodialysis Patients?

Chronic kidney disease (CKD) is associated with many adverse outcomes including mineral and bone disorders. The prevalence of fractures among patients with CKD exceeds that of the general population, due to impairments in bone quantity, bone quality, and abnormalities of neuromuscular function with profound effects on morbidity and mortality (1). Type 2 diabetes mellitus (T2DM), that is a major...

Cost-effectiveness of Pharmaceutical Interventions to Prevent Osteoporotic Fractures in Postmenopausal Women with Osteopenia

BACKGROUND To assess the cost-effectiveness of drug therapy to prevent osteoporotic fractures in postmenopausal women with osteopenia in Korea. METHODS A Markov cohort simulation was conducted for lifetime with a hypothetical cohort of postmenopausal women with osteopenia and without prior fractures. They were assumed to receive calcium/vitamin D supplements only or drug therapy (i.e., raloxi...

Osteoporotic Verterbal Compression Fractures

But, some of patients complain of uncontrolled persistent chronic pain and progressive collapse of vertebral body, post-traumatic kyphosis with or without neurologic deficits. It is well known that osteoporotic fracture is also associated with significant morbidity and mortality in postmenopausal women.8-12 There was an approximate 2-fold increase in risk of death following any clinical fractur...